Anti-inflammatory effects of rosmarinic acid-4-O-β-D-glucoside in reducing acute lung injury in mice infected with influenza virus.
Identifieur interne : 000B08 ( Main/Exploration ); précédent : 000B07; suivant : 000B09Anti-inflammatory effects of rosmarinic acid-4-O-β-D-glucoside in reducing acute lung injury in mice infected with influenza virus.
Auteurs : Jian-Xing Liu [République populaire de Chine] ; Ying Zhang [République populaire de Chine] ; Qiu-Ping Hu [République populaire de Chine] ; Ji-Qiang Li [République populaire de Chine] ; Yun-Tao Liu [République populaire de Chine] ; Qing-Guang Wu [République populaire de Chine] ; Jian-Guo Wu [République populaire de Chine] ; Xiao-Ping Lai [République populaire de Chine] ; Zhong-De Zhang [République populaire de Chine] ; Xiong Li [République populaire de Chine] ; Geng Li [République populaire de Chine]Source :
- Antiviral research [ 1872-9096 ] ; 2017.
Descripteurs français
- KwdFr :
- Analyse de survie, Animaux, Anti-inflammatoires non stéroïdiens (), Anti-inflammatoires non stéroïdiens (administration et posologie), Charge virale, Cinnamates (), Cinnamates (administration et posologie), Cytokines (analyse), Depsides (), Depsides (administration et posologie), Glucosides (), Glucosides (administration et posologie), Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (anatomopathologie), Lésion pulmonaire aigüe (), Lésion pulmonaire aigüe (anatomopathologie), Modèles animaux de maladie humaine, Poids du corps, Poumon (anatomopathologie), Poumon (virologie), Souris.
- MESH :
- administration et posologie : Anti-inflammatoires non stéroïdiens, Cinnamates, Depsides, Glucosides.
- analyse : Cytokines.
- anatomopathologie : Infections à Orthomyxoviridae, Lésion pulmonaire aigüe, Poumon.
- virologie : Poumon.
- Analyse de survie, Animaux, Anti-inflammatoires non stéroïdiens, Charge virale, Cinnamates, Depsides, Glucosides, Infections à Orthomyxoviridae, Lésion pulmonaire aigüe, Modèles animaux de maladie humaine, Poids du corps, Souris.
English descriptors
- KwdEn :
- Acute Lung Injury (pathology), Acute Lung Injury (prevention & control), Animals, Anti-Inflammatory Agents, Non-Steroidal (administration & dosage), Anti-Inflammatory Agents, Non-Steroidal (chemistry), Body Weight, Cinnamates (administration & dosage), Cinnamates (chemistry), Cytokines (analysis), Depsides (administration & dosage), Depsides (chemistry), Disease Models, Animal, Glucosides (administration & dosage), Glucosides (chemistry), Lung (pathology), Lung (virology), Mice, Orthomyxoviridae Infections (complications), Orthomyxoviridae Infections (pathology), Survival Analysis, Viral Load.
- MESH :
- chemical , administration & dosage : Anti-Inflammatory Agents, Non-Steroidal, Cinnamates, Depsides, Glucosides.
- chemical , analysis : Cytokines.
- chemical , chemistry : Anti-Inflammatory Agents, Non-Steroidal, Cinnamates, Depsides, Glucosides.
- complications : Orthomyxoviridae Infections.
- pathology : Acute Lung Injury, Lung, Orthomyxoviridae Infections.
- prevention & control : Acute Lung Injury.
- virology : Lung.
- Animals, Body Weight, Disease Models, Animal, Mice, Survival Analysis, Viral Load.
Abstract
Rosmarinic acid-4-O-β-D-glucoside (RAG) is a dicaffeoyl phenolic compound isolated from Sarcandra glabra (Thunb.) Nakai. Preliminary studies show that RAG has significant anti-inflammatory properties and can alleviate ear swelling in mice and the paw swelling in rats. Here, the anti-influenza effects of RAG were investigated in mice infected with A/FM/1/47 H1N1 virus. The survival rate and body weight were observed, the lung edema, virus copies, inflammatory cytokines (including IL-4, IL-5, TNF-α and IFN-γ) and oxidative damage indexes (including SOD, MDA, NO, and CAT) were measured. Moreover, immune cell recruitment in alveoli was measured with white blood cells and differential counts. Therapeutic RAG concentrations substantially improve the symptoms, mitigate body weight loss and alleviate lung edema induced by virus, thus improve survival protection effects. Furthermore, RAG was shown to regulate influenza virus-induced inflammatory cytokine expression, specifically by downregulating the Th1 cell cytokines IFN-γ, TNF-α and upregulating the Th2 cell cytokines IL-4, IL-5. Cell migration and infiltration were also diminished after RAG administration.
DOI: 10.1016/j.antiviral.2017.04.010
PubMed: 28461072
Affiliations:
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Le document en format XML
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Dongguan Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Traditional Chinese Medicine, Dongguan, 523808</wicri:regionArea><wicri:noRegion>523808</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Zhong De" sort="Zhang, Zhong De" uniqKey="Zhang Z" first="Zhong-De" last="Zhang">Zhong-De Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510120, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510120</wicri:regionArea><wicri:noRegion>510120</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xiong" sort="Li, Xiong" uniqKey="Li X" first="Xiong" last="Li">Xiong Li</name><affiliation wicri:level="1"><nlm:affiliation>Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510120, China. 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State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou University of Chinese Medicine, Guangzhou, 510006, China; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072</wicri:regionArea><wicri:noRegion>Hubei 430072</wicri:noRegion></affiliation></author><author><name sortKey="Lai, Xiao Ping" sort="Lai, Xiao Ping" uniqKey="Lai X" first="Xiao-Ping" last="Lai">Xiao-Ping Lai</name><affiliation wicri:level="1"><nlm:affiliation>Guangzhou University of Chinese Medicine, Guangzhou, 510006, China; Dongguan Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Traditional Chinese Medicine, Dongguan, 523808, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou University of Chinese Medicine, Guangzhou, 510006, China; Dongguan Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Traditional Chinese Medicine, Dongguan, 523808</wicri:regionArea><wicri:noRegion>523808</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Zhong De" sort="Zhang, Zhong De" uniqKey="Zhang Z" first="Zhong-De" last="Zhang">Zhong-De Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510120, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510120</wicri:regionArea><wicri:noRegion>510120</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xiong" sort="Li, Xiong" uniqKey="Li X" first="Xiong" last="Li">Xiong Li</name><affiliation wicri:level="1"><nlm:affiliation>Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510120, China. Electronic address: youren1994@aliyun.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510120</wicri:regionArea><wicri:noRegion>510120</wicri:noRegion></affiliation></author><author><name sortKey="Li, Geng" sort="Li, Geng" uniqKey="Li G" first="Geng" last="Li">Geng Li</name><affiliation wicri:level="1"><nlm:affiliation>Guangzhou University of Chinese Medicine, Guangzhou, 510006, China. Electronic address: lg@gzucm.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou University of Chinese Medicine, Guangzhou, 510006</wicri:regionArea><wicri:noRegion>510006</wicri:noRegion></affiliation></author></analytic><series><title level="j">Antiviral research</title><idno type="eISSN">1872-9096</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Lung Injury (pathology)</term><term>Acute Lung Injury (prevention & control)</term><term>Animals</term><term>Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)</term><term>Anti-Inflammatory Agents, Non-Steroidal (chemistry)</term><term>Body Weight</term><term>Cinnamates (administration & dosage)</term><term>Cinnamates (chemistry)</term><term>Cytokines (analysis)</term><term>Depsides (administration & dosage)</term><term>Depsides (chemistry)</term><term>Disease Models, Animal</term><term>Glucosides (administration & dosage)</term><term>Glucosides (chemistry)</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Mice</term><term>Orthomyxoviridae Infections (complications)</term><term>Orthomyxoviridae Infections (pathology)</term><term>Survival Analysis</term><term>Viral Load</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de survie</term><term>Animaux</term><term>Anti-inflammatoires non stéroïdiens ()</term><term>Anti-inflammatoires non stéroïdiens (administration et posologie)</term><term>Charge virale</term><term>Cinnamates ()</term><term>Cinnamates (administration et posologie)</term><term>Cytokines (analyse)</term><term>Depsides ()</term><term>Depsides (administration et posologie)</term><term>Glucosides ()</term><term>Glucosides (administration et posologie)</term><term>Infections à Orthomyxoviridae ()</term><term>Infections à Orthomyxoviridae (anatomopathologie)</term><term>Lésion pulmonaire aigüe ()</term><term>Lésion pulmonaire aigüe (anatomopathologie)</term><term>Modèles animaux de maladie humaine</term><term>Poids du corps</term><term>Poumon (anatomopathologie)</term><term>Poumon (virologie)</term><term>Souris</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Inflammatory Agents, Non-Steroidal</term><term>Cinnamates</term><term>Depsides</term><term>Glucosides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-Inflammatory Agents, Non-Steroidal</term><term>Cinnamates</term><term>Depsides</term><term>Glucosides</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Anti-inflammatoires non stéroïdiens</term><term>Cinnamates</term><term>Depsides</term><term>Glucosides</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term><term>Lésion pulmonaire aigüe</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Acute Lung Injury</term><term>Lung</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Acute Lung Injury</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Body Weight</term><term>Disease Models, Animal</term><term>Mice</term><term>Survival Analysis</term><term>Viral Load</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de survie</term><term>Animaux</term><term>Anti-inflammatoires non stéroïdiens</term><term>Charge virale</term><term>Cinnamates</term><term>Depsides</term><term>Glucosides</term><term>Infections à Orthomyxoviridae</term><term>Lésion pulmonaire aigüe</term><term>Modèles animaux de maladie humaine</term><term>Poids du corps</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rosmarinic acid-4-O-β-D-glucoside (RAG) is a dicaffeoyl phenolic compound isolated from Sarcandra glabra (Thunb.) Nakai. Preliminary studies show that RAG has significant anti-inflammatory properties and can alleviate ear swelling in mice and the paw swelling in rats. Here, the anti-influenza effects of RAG were investigated in mice infected with A/FM/1/47 H1N1 virus. The survival rate and body weight were observed, the lung edema, virus copies, inflammatory cytokines (including IL-4, IL-5, TNF-α and IFN-γ) and oxidative damage indexes (including SOD, MDA, NO, and CAT) were measured. Moreover, immune cell recruitment in alveoli was measured with white blood cells and differential counts. Therapeutic RAG concentrations substantially improve the symptoms, mitigate body weight loss and alleviate lung edema induced by virus, thus improve survival protection effects. Furthermore, RAG was shown to regulate influenza virus-induced inflammatory cytokine expression, specifically by downregulating the Th1 cell cytokines IFN-γ, TNF-α and upregulating the Th2 cell cytokines IL-4, IL-5. Cell migration and infiltration were also diminished after RAG administration.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Jian Xing" sort="Liu, Jian Xing" uniqKey="Liu J" first="Jian-Xing" last="Liu">Jian-Xing Liu</name></noRegion><name sortKey="Hu, Qiu Ping" sort="Hu, Qiu Ping" uniqKey="Hu Q" first="Qiu-Ping" last="Hu">Qiu-Ping Hu</name><name sortKey="Lai, Xiao Ping" sort="Lai, Xiao Ping" uniqKey="Lai X" first="Xiao-Ping" last="Lai">Xiao-Ping Lai</name><name sortKey="Li, Geng" sort="Li, Geng" uniqKey="Li G" first="Geng" last="Li">Geng Li</name><name sortKey="Li, Ji Qiang" sort="Li, Ji Qiang" uniqKey="Li J" first="Ji-Qiang" last="Li">Ji-Qiang Li</name><name sortKey="Li, Xiong" sort="Li, Xiong" uniqKey="Li X" first="Xiong" last="Li">Xiong Li</name><name sortKey="Liu, Yun Tao" sort="Liu, Yun Tao" uniqKey="Liu Y" first="Yun-Tao" last="Liu">Yun-Tao Liu</name><name sortKey="Wu, Jian Guo" sort="Wu, Jian Guo" uniqKey="Wu J" first="Jian-Guo" last="Wu">Jian-Guo Wu</name><name sortKey="Wu, Qing Guang" sort="Wu, Qing Guang" uniqKey="Wu Q" first="Qing-Guang" last="Wu">Qing-Guang Wu</name><name sortKey="Zhang, Ying" sort="Zhang, Ying" uniqKey="Zhang Y" first="Ying" last="Zhang">Ying Zhang</name><name sortKey="Zhang, Zhong De" sort="Zhang, Zhong De" uniqKey="Zhang Z" first="Zhong-De" last="Zhang">Zhong-De Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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